Located directly adjacent to the San Francisco Peninsula's main transportation artery, Highway 101, Opus Center Sierra Point boasts its own dedicated freeway interchange servicing the project. Just south of this interchange is Interstate 380 providing immediate access to Interstate 280's commute corridor and the management talent that resides in the upscale neighborhoods of Hillsborough, Woodside, Atherton and Los Altos Hills.

The site is in the heart of the Bio Technology and Life Science capital of the world. The 10-mile radius surrounding Sierra Point is home to over 50 life science companies including Amgen, Cell Genesys, Exelixis, Gilead Sciences and Applied Bio Systems.

Dedicated shuttles provide access to the Bay Area's regional and public transportation systems of BART, CalTrain, and CalTrans.